Folinic-Plus open bottle

WHAT IS FOLINIC-PLUS®?

Folinic-Plus is a vitamin B supplement that was designed by a physician to help reduce or prevent vitamin B6, B9 and B12 deficiencies at a reasonable cost.

Folinic-Plus® B6, B9, B12

B vitamins are essential for the body to utilize energy and all organ systems are dependent on them.  B vitamins are naturally found in a variety of foods, but certain health conditions and medications can decrease the body’s ability to absorb or utilize them which can lead to a deficiency.  Since B vitamins are water-soluble (excreted from the body daily), most must be replenished on a regular basis.

Folinic-Plus® is a dietary supplement with a balanced formula of:

• B6 - 50mg as Pyridoxal 5’-phosphate – an active form of B6
• B9 - 4mg as folinic acid (leucovorin, 5-formyltetrahydrofolate) – a reduced form of folate
• B12 - 2mg as Methylcobalamin – an active form of B12 which does not contain a cyanide group


Folinic-Plus® caplets may be beneficial to help vitamin B6, B9 & B12 deficiency if:

» Your medications are causing a vitamin B deficiency
» You are not getting the recommended vitamin intake through your diet

Some medications that are critical for a condition may interfere with your body’s absorption or utilization of B vitamins.

MANY MEDICATIONS MAY PUT PATIENTS AT RISK FOR VITAMIN DEFICIENCY

B6

  • Oral contraceptive use has been associated with B6 deficiency. There is some speculation that the biochemical effects may play a role in mood disorders, such as depression, via the tryptophan catabolic pathway.

B9/Folates

  • Epileptic drugs such as phenytoin (Dilantin®), carbamazepine (Carbatrol®, Tegretol®, Equetro®, Epitol®), and valproate (Depacon®) could reduce blood levels of folate. Taking folic acid supplements could also reduce blood levels of these medications.

B12

  • Metformin, the #1 type II diabetes medication, can cause B12 deficiency. Studies and case reports suggest that 10%–30% of patients who take metformin have reduced vitamin B12 blood levels.  Severity worsens with length of use.
  • Proton pump inhibitors may interfere with dietary B12 absorption.