Taking one tablet of Folinic-Plus® once per day is generally adequate. Patients should consult with their healthcare provider before using Folinic-Plus® and any non-prescription supplement.
- Vitamin B6 supplements might interact with cycloserine, an antibiotic used to treat tuberculosis, and worsen any seizures and nerve cell damage that the drug might cause.
- Taking certain epilepsy drugs could decrease vitamin B6 levels and reduce the drugs' ability to control seizures.
- Taking theophylline for asthma or another lung disease can reduce vitamin B6 levels and cause seizures.
- Very high doses of B6 can cause nerve damage. The NIH estimated tolerable upper limit of B6 in adults is 100mg.
- Folic acid could interfere with methotrexate when taken to treat cancer, psoriasis or arthritis. Folinic-Plus® can interfere with the therapeutic effect of methotrexate.
- Taking anti-epileptic medications such as phenytoin (Dilantin®), carbamazepine (Carbatrol®, Tegretol®, Equetro®, Epitol®), and valproate (Depacon®) could reduce blood levels of folate. Taking folic acid supplements could also reduce blood levels of these medications.
- Taking sulfasalazine (Azulfidine®) for ulcerative colitis could reduce the body's ability to absorb folate and cause folate deficiency.
- B12 may interfere with Chloramphenicol, an antibiotic that is used to treat certain infections.
- Proton Pump Inhibitors, such as omeprazole (Prilosec®), pantoprazole (Protonix®) and lansoprazole (Prevacid®), that are used to treat acid reflux may interfere with B12 absorption.
- Histamine H2 receptor antagonists, such as cimetidine (Tagamet®), famotidine (Pepcid®), and ranitidine (Zantac®), that are used to treat peptic ulcer disease may interfere with B12 absorption.
Tell your doctor, pharmacist and other health care providers about any dietary supplements and medicines you take. They all contain chemicals which frequently interact.
One recommended concept to remember is that by definition vitamins are needed in adequate amounts to facilitate chemical reactions in the body. More is not better and more can be harmful in some circumstances. Fortunately, B vitamins are water-soluble, so excess amounts are usually excreted from the body rather than stored. This makes the risk of vitamin B toxicity low in most cases.