Dosing Frequency and Body Stores
Once-daily dosing of Folinic-Plus® is generally adequate. Patients should consult with their physician before using Folinic-Plus® and any non-prescription supplement.
There is a difference between serum half-life (how fast levels in the blood decrease back to baseline) after an oral or IV dose of medication and tissue levels that determine the body’s ability to store and use many substances.
Folates are more complicated because of binding proteins, active transport and varying rates of catabolism. In humans, turnover varies in different tissues. Body stores in normal adults are estimated at 5-10 mg (mostly in the liver) with estimated daily utilization of 0.2-0.6 mg/day. Therefore, the average available store is >2 weeks.
The human body can store a few years’ worth of B12, mostly in the liver.